盗墓笔记,好看的言情小说

Create high-quality medication to benefit
patients worldwide.

Therapeutic Areas R&D Platforms Pipeline & Programs Collaboration

PROTAC Targeted Protein Degradation（TPD）Platform

Traditional small molecule drugs treat diseases by binding to target proteins and subsequently modulating their functions. Inhibition of protein function can be achieved at the gene level (DNA editing), transcriptional level (siRNA and ASO), and protein level (inhibitors and TPDs). Proteolysis targeting chimera (PROTAC) technology applies bifunctional small molecules to the targeted proteins with degradation (TPD), and this technology has been considered to be revolutionary in biopharmaceuticals since it has the potential of targeting non-druggable targets and solving the resistance issue of small molecule drugs. Since its inception in 2001, PROTAC technology has been widely utilized in academia and industry. Due to the relatively large molecular weight and other issues, addressing the oral bioavailability and stability of this type of compounds has been a challenge for PROTAC drug development. Hinova has been building a PROTAC technology platform since 2016, and has developed a few PROTAC projects against multiple targets. Currently an androgen receptor (AR) PROTAC molecules is in Phase-I clinical trials.

Competitive Advantages of Hinova PROTAC Platform

Deuterated Drug R&D Platform

The study of deuterated N-methyl hydrogen on the inhibition of morphine enzyme oxidation in 1961 has drawn great interests of the pharmaceutical industry ever since.

Since the breaking of carbon-hydrogen bonds is a common feature in drug metabolism, and the breaking of carbon-deuterium bonds is more difficult. The slower metabolic rate of deuterated compounds can increase the half-life or/and exposure of the active drug, and it has the potential of reducing the dosing frequency or dosage. Another advantage is that this substitution can also reduce toxicity by reducing the formation of toxic metabolites.

The FDA and NMPA have approved the first deuterated drug, AUSTEDO? (deutetrabenazine), for the treatment of Huntington's chorea. HC-1119, the first deuterium-generation drug for prostate cancer manufactured by Hinova, has entered Phase-III clinical studies in Hinova.

Competitive Advantages of Hinova Deuteration Technology Platform

Targeted Drug Identification and Validation Platfo

During drug discovery, proper target identification is the most important step.
A good target is supposed to be safe, effective, druggable and meets medical and market needs.
Our R&D team is comprised of accomplished experts in biology, pharmaceutical chemistry, pharmacokinetics, pharmacology and clinical operation, who established a solid foundation for the identification and validation of new drug targets, and the development of pipelines.